BMM特刊精选|软骨组织修复与再生的生物材料方法

特刊详情

客座编辑

• 王东安，香港城市大学/瑞典卡罗林斯卡医学院刘鸣炜复修医学中心(香港)

主题范围

Cartilage repair and regeneration remain an unmet need for orthopedic health services. Given the avascular and aneural nature of cartilaginous tissues, once damaged, recovery via self-reparation may only occur in a limited capacity, efficacious therapy therefore substantially relies on engraftment of cartilaginous autografts or engineered cartilage.

The mission of tissue engineering is to manually produce human tissues or organs and integrate these living products into a patient’s body as grafts for reparative or regenerative purposes. Successful engraftment of engineered tissues critically depends on proper management and control of interactions between therapeutic cells and biomaterial scaffolds. Biomaterials play a key role to facilitate functional cells’ growth and development into neo-tissues or neo-organs, whether this occurs in a petri dish or on-site in the human body. Once a graft is implanted into a biological system, it will be remodeled by the host, more or less, following certain biophysical and biochemical principles.

Accordingly, this Collection focuses on tissue engineering strategies and particularly emphasizes biomaterials approaches and associated challenges to the repair and regeneration of cartilage tissue. This Collection will include original research articles and topical reviews covering the following key areas:

• Biomaterials for cartilage repair and regeneration: development, approach and analysis
• Pre/clinical trials for cartilage repair and regeneration with engineered grafts
• Biological mechanism of cartilage regeneration with engineered grafts
• Physiological and pathological responses to engineered cartilage grafts
• Biomaterials for imaging of cartilage repair and regeneration
• Repair and regeneration of all types of cartilage, including articular hyaline cartilage, fibrocartilage of meniscus and intervertebral disc, and osteochondral, costal, auricular, nasal, temporomandibular, tracheal cartilage and so on