21 4月 2023 gabriels



  • 王东安,香港城市大学/瑞典卡罗林斯卡医学院刘鸣炜复修医学中心(香港)


Cartilage repair and regeneration remain an unmet need for orthopedic health services. Given the avascular and aneural nature of cartilaginous tissues, once damaged, recovery via self-reparation may only occur in a limited capacity, efficacious therapy therefore substantially relies on engraftment of cartilaginous autografts or engineered cartilage.

The mission of tissue engineering is to manually produce human tissues or organs and integrate these living products into a patient’s body as grafts for reparative or regenerative purposes. Successful engraftment of engineered tissues critically depends on proper management and control of interactions between therapeutic cells and biomaterial scaffolds. Biomaterials play a key role to facilitate functional cells’ growth and development into neo-tissues or neo-organs, whether this occurs in a petri dish or on-site in the human body. Once a graft is implanted into a biological system, it will be remodeled by the host, more or less, following certain biophysical and biochemical principles.

Accordingly, this Collection focuses on tissue engineering strategies and particularly emphasizes biomaterials approaches and associated challenges to the repair and regeneration of cartilage tissue. This Collection will include original research articles and topical reviews covering the following key areas:

  • Biomaterials for cartilage repair and regeneration: development, approach and analysis
  • Pre/clinical trials for cartilage repair and regeneration with engineered grafts
  • Biological mechanism of cartilage regeneration with engineered grafts
  • Physiological and pathological responses to engineered cartilage grafts
  • Biomaterials for imaging of cartilage repair and regeneration
  • Repair and regeneration of all types of cartilage, including articular hyaline cartilage, fibrocartilage of meniscus and intervertebral disc, and osteochondral, costal, auricular, nasal, temporomandibular, tracheal cartilage and so on



Editorial: Focus issue on biomaterials approaches to the repair and regeneration of cartilage tissue

Kang Sun et al 2023 Biomed. Mater. 18 030201


Topical Reviews

Biomaterials-assisted exosomes therapy in osteoarthritis

Manyu Chen et al 2022 Biomed. Mater. 17 022001


Synovial macrophages in cartilage destruction and regeneration—lessons learnt from osteoarthritis and synovial chondromatosis

Yingjie Li et al 2022 Biomed. Mater. 17 012001



A cell-free ROS-responsive hydrogel/oriented poly(lactide-co-glycolide) hybrid scaffold for reducing inflammation and restoring full-thickness cartilage defects in vivo

Xinyu Wu et al 2021 Biomed. Mater. 16 064101


A transcriptome sequencing study on the effect of macro-pores in hydrogel scaffolds on global gene expression of laden human cartilage chondrocytes

Junqiang Xue et al 2022 Biomed. Mater. 17 044102


Differentiation of equine mesenchymal stem cells into cells of osteochondral lineage: potential for osteochondral tissue engineering

Hiu Wa Cheng et al 2022 Biomed. Mater. 17 064102


Effect of passage number of genetically modified TGF-β3 expressing primary chondrocytes on the chondrogenesis of ATDC5 cells in a 3D coculture system

Ke Chen et al 2022 Biomed. Mater. 17 024102


Hydrogels with tunable modulus regulate chondrocyte microaggregates growth for cartilage repair

Jing Chen et al 2022 Biomed. Mater. 17 014106


RGD-incorporated biomimetic cryogels for hyaline cartilage regeneration

Rachel H Koh et al 2022 Biomed. Mater. 17 024106


Regional-specific meniscal extracellular matrix hydrogels and their effects on cell–matrix interactions of fibrochondrocytes

Jinglei Wu et al 2022 Biomed. Mater. 17 014105


Superlarge living hyaline cartilage graft contributed by the scale-changed porous 3D culture system for joint defect repair

Hang Yao et al 2022 Biomed. Mater. 17 064101


The co-influence of hyaluronic acid and collagen on the development of an engineered annulus tissue model with bone marrow stromal cells

Yon Jin Chuah et al 2022 Biomed. Mater. 17 054101


Three-dimensional culture and chondrogenic differentiation of mesenchymal stem cells in interconnected collagen scaffolds

Yan Xie et al 2022 Biomed. Mater. 17 034103


Scaffold-free approaches for the fabrication of engineered articular cartilage tissue

Kang Sun et al 2022 Biomed. Mater. 17 022005


Biomedical Materials

  • 2021年影响因子:4.103  Citescore:5.5
  • Biomedical Materials(BMM)期刊是IOP出版社旗下基于同行评议的学术期刊,创刊于2006年。该刊关注如何利用生物医学材料解决日益增长的人类健康需求,包括但不限于组织工程以及、再生医学、干细胞、药物/因子递送、纳米医学、癌症诊断和治疗等领域的应用基础研究和临床转化研究。