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JPhysD研究文章|流光放电对小鼠B16F10黑色素瘤局部复发的抑制作用

28 3月 2025 gabriels

Plasma-based cancer therapy presents a novel approach to treating oncologic diseases. One promising application is post-surgical plasma treatment to reduce the risk of local recurrence after tumor resection. However, a major challenge in the post-surgical treatment using plasma is the limited experimental evidence. This study provides in vivo evidence demonstrating that streamer discharge can significantly reduce the local recurrence rate of B16F10 melanoma tumors in mice. Ten-minute treatments of tumor resection sites reduced the recurrence rate by approximately 50%. No significant abnormalities related to plasma treatment were observed throughout the experiments. The cytotoxic effect of streamer discharge was also demonstrated in vitro, where apoptosis and necrosis were observed in B16F10 cells.

文章介绍

Inhibitory effect of streamer discharge on the local recurrence of B16F10 melanoma tumor in mice

Ryuichiro Ito, Ryota Sumitomo, Misa Iizawa, Hideyuki Yanai and Ryo Ono

通讯作者：

Ryo Ono，日本东京大学

期刊介绍

Journal of Physics D: Applied Physics

2023年影响因子：3.1 Citescore：6.8
Journal of Physics D: Applied Physics（JPhysD，《物理学报D：应用物理》）发表应用物理各领域的前沿研究和综述，具体包括：应用磁学和磁性材料、半导体和光子学、低温等离子体和等离子表面相互作用、凝聚态物理、表面科学和纳米结构、生物物理以及能源等六个领域。文章类型包括原创性论文、研究路线图、通讯以及每年针对热点研究的专题综述和特刊。